<scp>IL6</scp> Regulates Glutamate/Haptoglobin‐Induced Ferroptosis via the <scp>JAK2</scp> / <scp>STAT3</scp> Axis

accumulation. IL6 silencing attenuated OGD-induced apoptosis, effects that were significantly abolished by Glu or HP. In myocardial I/R and MCAO models, IL6 knockdown preserved cardiac function, reduced cerebral infarction, alleviated oxidative stress, and mitigated ferroptosis, whereas Glu or HP co-treatment reversed these benefits. Mechanistically, IL6 silencing inhibited JAK2/STAT3 activation, while colivelin treatment reinstated pathway phosphorylation and ferroptosis. IL6 downregulation alleviates cardiac and cerebral I/R injuries by suppressing ferroptosis through regulation of the JAK2/STAT3 pathway.