Lineage-Specific Venom Gene Expression Shapes Chemical Diversity in Cephalopods

expression to specialized secretory cells within squid and cuttlefish venom glands. Together, these findings reposition SE-CTX as part of an evolutionarily and chemically diverse venom system, rather than an isolated venom protein, and establish cephalopods as a key lineage for investigating how new venom genes arise, diversify, and are integrated into functional venom arsenals.

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Publication Details

Journal
bioRxiv (Cold Spring Harbor Laboratory)
Published
2026-04-10
DOI
https://doi.org/10.64898/2026.04.09.716377
Primary Topic
Marine Invertebrate Physiology and Ecology
Type
article
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article

Lineage-Specific Venom Gene Expression Shapes Chemical Diversity in Cephalopods

Caroline B. Albertin, José Ramón Pardos-Blas, Beatrix Ueberheide, Jennifer B. McCarthy et al.
bioRxiv (Cold Spring Harbor Laboratory)
Marine Invertebrate Physiology and Ecology
article

Lineage-Specific Venom Gene Expression Shapes Chemical Diversity in Cephalopods

Caroline B. Albertin, José Ramón Pardos-Blas, Beatrix Ueberheide, Jennifer B. McCarthy, Benjamin-Florian Hempel, Kim N. Kirchhoff, Mandë Holford, Saurabh Attarde, Favour Achimba, Mariam Gelashvili, David Sharer, Afeeda Ali, Belkes Stambouli, Melvin Williams, M Praveena Naidu, Ioana Clotea
article en

Abstract

expression to specialized secretory cells within squid and cuttlefish venom glands. Together, these findings reposition SE-CTX as part of an evolutionarily and chemically diverse venom system, rather than an isolated venom protein, and establish cephalopods as a key lineage for investigating how new venom genes arise, diversify, and are integrated into functional venom arsenals.

bioRxiv (Cold Spring Harbor Laboratory)
The Graduate Center, CUNY (US), Marine Biological Laboratory (US), City University of New York (US), Hunter College (US), NYU Langone Health (US), Evolutionary Genomics (United States) (US), Freie Universität Berlin (DE)
Life below water
Openalex Percentile: Top 21%
Marine Invertebrate Physiology and Ecology
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