Daklakamitocins A–I, Brominated Maytansinoid Glycosides from <i>Amycolatopsis</i> sp. CK6 with Antiproliferative Activity
) exhibited markedly stronger cytotoxicity against human cancer cell lines than its chlorinated analogue, ansacarbamitocin A, suggesting that bromination may contribute to enhanced antiproliferative activity. These findings expand the chemical diversity of maytansinoid metabolites and highlight halide supplementation as an effective strategy for generating brominated congeners for structure-activity comparison.
Authors
- Hyunkyu Sang (ORCID: https://orcid.org/0000-0002-7459-5217)
- Yern‐Hyerk Shin
- Kyuho Moon (ORCID: https://orcid.org/0000-0003-1287-3514)
- Hongju Jeong
- Ran Hui Kim
- Munhyung Bae (ORCID: https://orcid.org/0000-0002-7771-7320)
- Xuan‐Hao Bui (ORCID: https://orcid.org/0009-0006-7962-6998)
- Soohyun Um (ORCID: https://orcid.org/0009-0008-9428-8936)
- Thinh T. M. Bui
- Wonkyung Kim
- Joonhwan Yoon
Institutions
- Kookmin University (KR)
- Gachon University (KR)
- Kyung Hee University (KR)
- Albany College of Pharmacy and Health Sciences (US)
- Chonnam National University Hospital (KR)
- Ho Chi Minh City University of Education (VN)
- Institut thématique Génétique, génomique et bioinformatique (FR)
- Forest Products Laboratory (US)
- Research Institute for Bioscience and Biotechnology (NP)
- International Drug Development (FR)
- Harvard Stem Cell Institute (US)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1021/acs.jnatprod.6c00002
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Agriculture, Food and Rural Affairs
- National Research Foundation of Korea