ParetoEnsembles.jl: A Julia Package for Multiobjective Parameter Estimation Using Pareto Optimal Ensemble Techniques.

through an incremental update scheme, and adds multi-chain parallel execution for improved front coverage. We demonstrate the package on a cell-free gene expression model fitted to experimental data and a blood coagulation cascade model with ten estimated rate constants and three objectives. A controlled synthetic-data study reveals parameter identifiability structure, with individual rate constants off by several-fold yet model predictions accurate to 6-7%. A five-replicate coverage analysis confirms that timing features are reliably covered while peak amplitude is systematically overconfident. Validation against published experimental thrombin generation data demonstrates that the ensemble predicts held-out conditions to within 1-10% despite inherent model approximation error. By making ensemble generation lightweight and accessible, ParetoEnsembles.jl aims to lower the barrier to routine uncertainty characterization in mechanistic modeling.

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PubMed
Published
2026-03-31
Primary Topic
Blood properties and coagulation
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article
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article

ParetoEnsembles.jl: A Julia Package for Multiobjective Parameter Estimation Using Pareto Optimal Ensemble Techniques.

Jeffrey D. Varner
PubMed
Blood properties and coagulation
article

ParetoEnsembles.jl: A Julia Package for Multiobjective Parameter Estimation Using Pareto Optimal Ensemble Techniques.

Jeffrey D. Varner
article en

Abstract

through an incremental update scheme, and adds multi-chain parallel execution for improved front coverage. We demonstrate the package on a cell-free gene expression model fitted to experimental data and a blood coagulation cascade model with ten estimated rate constants and three objectives. A controlled synthetic-data study reveals parameter identifiability structure, with individual rate constants off by several-fold yet model predictions accurate to 6-7%. A five-replicate coverage analysis confirms that timing features are reliably covered while peak amplitude is systematically overconfident. Validation against published experimental thrombin generation data demonstrates that the ensemble predicts held-out conditions to within 1-10% despite inherent model approximation error. By making ensemble generation lightweight and accessible, ParetoEnsembles.jl aims to lower the barrier to routine uncertainty characterization in mechanistic modeling.

PubMed
Cornell University (US)
Openalex Percentile: Top 20%
Blood properties and coagulation
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