ParetoEnsembles.jl: A Julia Package for Multiobjective Parameter Estimation Using Pareto Optimal Ensemble Techniques.
through an incremental update scheme, and adds multi-chain parallel execution for improved front coverage. We demonstrate the package on a cell-free gene expression model fitted to experimental data and a blood coagulation cascade model with ten estimated rate constants and three objectives. A controlled synthetic-data study reveals parameter identifiability structure, with individual rate constants off by several-fold yet model predictions accurate to 6-7%. A five-replicate coverage analysis confirms that timing features are reliably covered while peak amplitude is systematically overconfident. Validation against published experimental thrombin generation data demonstrates that the ensemble predicts held-out conditions to within 1-10% despite inherent model approximation error. By making ensemble generation lightweight and accessible, ParetoEnsembles.jl aims to lower the barrier to routine uncertainty characterization in mechanistic modeling.
Authors
- Jeffrey D. Varner (ORCID: https://orcid.org/0000-0002-2558-7026)
Institutions
- Cornell University (US)
Publication Details
- Journal
- PubMed
- Published
- 2026-03-31
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00