Development of an Empirical Approach for the Prediction of Cytochrome P450-Based Drug–Drug Interactions in Pediatric Patients
: This study demonstrates that the proposed approach of considering both ontogeny and allometric scaling represents a robust and reasonable method to anticipate the extent of pediatric CYP-based DDIs when adult PK data are available.
Authors
- Veronica Di Paolo (ORCID: https://orcid.org/0000-0003-2706-6774)
- Luigi Quintieri (ORCID: https://orcid.org/0000-0001-7403-0921)
- Italo Poggesi (ORCID: https://orcid.org/0000-0003-3079-6954)
- Francesco Maria Ferrari
Institutions
- University of Padua (IT)
- Quantitative BioSciences (US)
- Météo-France (FR)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2026-04-10
- DOI
- https://doi.org/10.3390/ph19040608
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00