CRH neurons in the AM-ACC circuit drive chronic pain and anxiety comorbidity
neural circuit in encoding the emotional dimen-sion of pain. It provides a novel theoretical framework for targeting this neural circuit in the treatment of pain-anxiety comorbidity.
Authors
- Chaofan Lu (ORCID: https://orcid.org/0000-0003-1401-7455)
- Yaoyao Zhang
- Qi Zhao (ORCID: https://orcid.org/0000-0003-0826-6068)
- Jing Zhang (ORCID: https://orcid.org/0000-0003-3064-7625)
- Sen Zhao (ORCID: https://orcid.org/0000-0002-1014-0280)
- Tianen Si
- X Y Ren
- Liujie Zhao
- Weidong Zang
- Jing Cao
- Ziang Li
Institutions
- Neurosciences Institute (US)
- Zhengzhou University (CN)
- China Academy of Chinese Medical Sciences (CN)
- Henan Provincial Chest Hospital (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2026-04-10
- DOI
- https://doi.org/10.3389/fnins.2026.1809769
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00