Molecular Mechanisms of Zhizhu Kuanzhong Capsule in the Treatment of Co-Morbid Anxiety and Depression of Functional Dyspepsia: Network Pharmacology, Molecular Docking and In Vivo Validation
: ZZKZ effectively ameliorates the disordered gut-brain interaction and mitigates anxiety-like and depression-like behaviors, which might be modulated by the hippocampal monoaminergic system and hypothalamic-pituitary-adrenal axis response.
Authors
- Zhuanglong Xiao
- Lei Zhang (ORCID: https://orcid.org/0000-0003-4921-8986)
- Tao Bai
- Xiaohua Hou
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Biomedicines
- Published
- 2026-04-10
- DOI
- https://doi.org/10.3390/biomedicines14040867
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Huazhong University of Science and Technology
- Tongji University
- Tongji Medical College, Huazhong University of Science and Technology