Case Report: Giant undifferentiated pleomorphic sarcoma of the breast combined with contralateral high-grade intraductal carcinoma

This article reports an exceptionally rare case of a 43-year-old female presenting with concurrent giant pleomorphic undifferentiated sarcoma and high-grade intraductal carcinoma of the contralateral breast. The tumor, remarkably large and comparable in size to a basketball, presented significant diagnostic and therapeutic challenges. Following a multidisciplinary consultation, the patient underwent a comprehensive treatment regimen, which included left mastectomy, modified radical mastectomy, vacuum-assisted closure (VSD) negative pressure drainage, radiotherapy, and endocrine therapy for the high-grade intraductal carcinoma. Post-treatment follow-up over a period of 2 to 5 years revealed a satisfactory recovery with no evidence of recurrence or metastasis. This case underscores the critical role of a multidisciplinary approach in managing rare and complex breast malignancies and highlights the potential for favorable outcomes even in cases involving exceptionally large tumors.