A Novel Antioxidant Peptide Cath‐Np Derived from <i>Nanorana parkeri</i> Attenuates UVB‐Induced Skin Photodamage in Mice

and 2,2-diphenyl-1-picrylhydrazyl radical scavenging, potassium ferricyanide reducing, and DNA-protecting effects. Cath-Np was also able to reduce the abnormal elevation of reactive oxygen species and neutrophil migration in zebrafish. Notably, Cath-Np significantly reduced the oxidative damage, inhibited inflammatory factor production by suppressing the activation of mitogen-activated protein kinase and p53 while activating the Nrf2 signaling pathways, and consequently exerted a protective effect against skin photodamage in UVB-irradiated mice. Hence, our results help to better understand the adaptation mechanism of N. parkeri to the extreme environmental conditions of the Qinghai-Xizang Plateau. Meanwhile, they also highlight the potential application of Cath-Np as a protective agent against damage caused by UVB radiation and offer a novel candidate molecule for developing anti-photodamage drugs and cosmetic products.