Reduced sensory attenuation as a marker of pathological fatigue: Evidence from Parkinson's disease

group, reduced sensory attenuation was strongly associated with greater subjective fatigue and perceived effort, but not with motor symptom severity, disease duration, or other non-motor symptoms commonly co-occurring with fatigue. These findings provide empirical evidence that impaired sensory attenuation may be a fundamental mechanism underlying pathological fatigue in PD. Importantly, this impairment appears unique and specific to fatigue, as it does not correlate with other clinical features of PD or with other nonmotor symptoms. The selective link between sensory attenuation and fatigue offers a promising avenue for the development of targeted interventions and underscores the potential of sensory attenuation as a biomarker of pathological fatigue.