Peak oxygen consumption is positively associated with estimates of oxygen extraction and microvascular blood volume in veterans with chronic kidney disease
Peak oxygen consumption is associated with peak heart rate, oxygen extraction, and microvascular blood volume in patients with chronic kidney disease (CKD), highlighting the importance of cardiovascular and skeletal muscle health in this patient population. Future studies are necessary to determine which exercise approaches are most efficacious at enhancing cardiorespiratory fitness and whether, and to what extent, improvements in cardiorespiratory fitness result from changes in cardiovascular factors, skeletal muscle factors, or a combination of both.
Authors
- Jared M. Gollie (ORCID: https://orcid.org/0000-0003-1066-7389)
- Samir S. Patel (ORCID: https://orcid.org/0000-0001-8214-3790)
- Nawar Shara (ORCID: https://orcid.org/0000-0002-9005-252X)
- Alexander Libin (ORCID: https://orcid.org/0000-0001-7847-3463)
- Peter Kokkinos (ORCID: https://orcid.org/0000-0001-6055-7634)
- Aaron B. Holley (ORCID: https://orcid.org/0000-0002-6249-6596)
- Cooper Hazel
- David J. Kim (ORCID: https://orcid.org/0000-0001-8102-3471)
- Marc R. Blackman
Institutions
- MedStar Washington Hospital Center (US)
- Georgetown University (US)
- George Washington University (US)
- Rutgers Sexual and Reproductive Health and Rights (NL)
- Washington DC VA Medical Center (US)
Publication Details
- Journal
- American Journal of Physiology-Renal Physiology
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1152/ajprenal.00424.2025
- Primary Topic
- Cardiovascular and exercise physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- Office of Research and Development