Histone decrotonylation plays a distinct role in HIV latency
T cells, and brain microglia from simian immunodeficiency virus-infected nonhuman primates and participants enrolled in the Last Gift rapid research autopsy cohort, highlighting HDCR as a promising therapeutic target for HIV latency.
Authors
- Y. Tang
- David M. Margolis (ORCID: https://orcid.org/0000-0001-5714-0002)
- Marie Nearing (ORCID: https://orcid.org/0000-0002-5261-4544)
- Satya Dandekar (ORCID: https://orcid.org/0000-0002-6346-8028)
- Ryan H. Gumpper (ORCID: https://orcid.org/0000-0003-1309-3069)
- Guochun Jiang (ORCID: https://orcid.org/0000-0003-1911-5089)
- Sara Gianella (ORCID: https://orcid.org/0000-0002-9927-0849)
- Venkat R. Chirasani (ORCID: https://orcid.org/0000-0003-1416-0438)
- Benjamin D. Varco-Merth
- Afam A. Okoye
- Nancie M. Archin
- Davey Smith (ORCID: https://orcid.org/0000-0003-3603-1733)
- Xiaoyi Li (ORCID: https://orcid.org/0009-0000-3221-436X)
- Dajiang Li
Institutions
- Oregon National Primate Research Center (US)
- University of North Carolina at Chapel Hill (US)
- University of California San Diego (US)
- University of California Davis Medical Center (US)
Publication Details
- Journal
- Science Advances
- Published
- 2026-04-10
- DOI
- https://doi.org/10.1126/sciadv.aec0149
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Oregon National Primate Research Center
- National Institute of Mental Health
- National Institute of Allergy and Infectious Diseases
- Center for AIDS Research, University of North Carolina at Chapel Hill