Neuron-specific epigenetic repression of <i>Cdk5</i> impairs hippocampal-dependent memory in male and female mice
acetylation in neurons is necessary for hippocampal memory in both sexes, providing new insight into sex-specific epigenetic regulation of memory.
Authors
- Kiara L. Rodríguez-Acevedo (ORCID: https://orcid.org/0000-0002-7839-771X)
- Elizabeth A. Heller (ORCID: https://orcid.org/0000-0002-2984-8705)
- Ajinkya Sase
- Julia Winter (ORCID: https://orcid.org/0000-0001-8518-0167)
- Kyle S. Czarnecki
- Megan I Alvarez
Institutions
- Translational Therapeutics (United States) (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-10
- DOI
- https://doi.org/10.64898/2026.04.08.716689
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- University of Pennsylvania
- Virginia Commonwealth University