Cell Death Induced by Homoisoflavonoid Brazilin and Its Semisynthetic Derivatives on MDA-MB-231 and MCF7 Breast Cancer Cell Lines
affected the nontumorigenic MCF10A cells. Notably, the methylated compound exhibited minimal biological activity, as it did not significantly affect cell viability across the tested cell lines and induced no substantial transcriptional changes. Collectively, our results suggest that brazilin and its acetylated derivative induce mitochondrial stress and cell death in triple-negative breast cancer cells, potentially involving endoplasmic reticulum stress pathways.
Authors
- Tapan Sharma (ORCID: https://orcid.org/0000-0003-2495-2236)
- Mario Ordóñez (ORCID: https://orcid.org/0000-0001-9395-7079)
- Miriam D. Zuñiga‐Eulogio (ORCID: https://orcid.org/0000-0003-2904-8350)
- Alberto Hernández-Moreno (ORCID: https://orcid.org/0009-0000-9118-1959)
- Michael Quinteros (ORCID: https://orcid.org/0000-0002-0779-2026)
- Tadeo Hernández-Moreno
- Carla Coste-Sanchez
- TERESITA PADILLA-BENAVIDES
- Monserrat Olea-Flores
- Napoleón Navarro-Tito
Institutions
- Wesleyan University (US)
- University of Massachusetts Chan Medical School (US)
- Universidad Autónoma de Guerrero (MX)
- Universidad Autónoma del Estado de Morelos (MX)
Publication Details
- Journal
- ACS Omega
- Published
- 2026-04-10
- DOI
- https://doi.org/10.1021/acsomega.6c00504
- Primary Topic
- Biological Stains and Phytochemicals
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Consejo Nacional de Ciencia y Tecnología