Therapy-specific motoneuron activation with epidural and dorsal root ganglion stimulation in spinal cord injury
Epidural and dorsal root stimulation have emerged as promising therapies to restore function after spinal cord injury. However, how each modality uniquely or jointly engages spinal circuits remains unclear. To address this, we analyzed leg electromyography (EMG) responses to epidural stimulation (ES) and dorsal root ganglia stimulation (DRGS) delivered to the lumbosacral cord in the same individuals.
Authors
- K. A. Fernandez (ORCID: https://orcid.org/0000-0002-3231-9003)
- Peter J. Grahn (ORCID: https://orcid.org/0000-0002-2976-814X)
- Andrew R. Thoreson (ORCID: https://orcid.org/0000-0002-8449-855X)
- Megan L. Gill
- Daniel D. Veith (ORCID: https://orcid.org/0000-0001-8250-3848)
- Ryan Solinsky (ORCID: https://orcid.org/0000-0002-7121-8678)
- Jon Hagedorn
- Dimitry G. Sayenko (ORCID: https://orcid.org/0000-0002-4154-6873)
- Kristin D. Zhao (ORCID: https://orcid.org/0000-0001-7598-8197)
- Margaux B. Linde
- Mark A. Bendel
- Candee J. Mills
- Rayyan A. Iqbal (ORCID: https://orcid.org/0009-0004-9544-9819)
- Anders J. Asp (ORCID: https://orcid.org/0000-0002-7793-9951)
Institutions
- Houston Methodist (US)
- University of Illinois Urbana-Champaign (US)
- WinnMed (US)
Publication Details
- Journal
- Journal of Neurophysiology
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1152/jn.00438.2025
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Minnesota Office of Higher Education
- Mayo Foundation for Medical Education and Research
- National Institute of Neurological Disorders and Stroke