Radial constraint of plastically compressed human dermo-epidermal skin substitutes mitigates <i>in vitro</i> contraction and enhances structural maturity
- smooth muscle actin expression. Furthermore, the epidermal layer in contraction-protected substitutes exhibited improved structural organization. Overall, the ASD provides a user-friendly and effective engineering solution to mitigate contraction in bioengineered skin substitutes, enhancing their stability and reproducibility for preclinical applications. This approach may contribute to improving the reliability of advanced skin grafts for future clinical use.
Authors
- Mirko Meboldt (ORCID: https://orcid.org/0000-0001-5828-5406)
- Roth Devi Long
- Thomas Biedermann (ORCID: https://orcid.org/0000-0002-6438-8791)
- Luca Pontiggia (ORCID: https://orcid.org/0000-0002-5553-8997)
- Jessica Polak
- Vanuchija Someswaran
- Ueli Moehrlen
- Agnes Klar
Institutions
- University of Zurich (CH)
- ETH Zurich (CH)
- Institute for Biomedical Engineering (CH)
- Center for Pediatric Endocrinology Zurich (CH)
- University Children's Hospital Zurich (CH)
Publication Details
- Journal
- Biofabrication
- Published
- 2026-04-10
- DOI
- https://doi.org/10.1088/1758-5090/ae5e0c
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondation Gaydoul