Efficient Synthesis of 1,4,2‐Dioxazepines via [4+3] Cyclization of <i>p</i> <scp>‐QMs</scp> With In Situ Generated <i>N</i> ‐Electron‐Withdrawing Group Nitrones
ABSTRACT An efficient [4+3] cyclization strategy has been developed that exploits p ‐QMs and N ‐(EWG) nitrones generated in situ from N‐hydroxy(sulfonylmethyl)carbamates, enabling direct access to 1,4,2‐dioxazepines under mild conditions with broad substrate scope and gram‐scale scalability. This work expands the synthetic utility of N ‐(EWG) nitrones and offers a new route to dioxazepines.
Authors
- Yun‐Qing Jia (ORCID: https://orcid.org/0000-0002-3640-8097)
- Ci Ding
- Guang‐Wei Wang
- Song Hu
- Min Xiang (ORCID: https://orcid.org/0009-0008-8063-6864)
- Li‐Wen Shen (ORCID: https://orcid.org/0009-0004-9657-6158)
Institutions
- Zunyi Normal College (CN)
Publication Details
- Journal
- Journal of Heterocyclic Chemistry
- Published
- 2026-04-10
- DOI
- https://doi.org/10.1002/jhet.70198
- Primary Topic
- Synthesis of heterocyclic compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00