A Randomized, Double-Blinded, Placebo-Controlled Trial of Homeopathy in Acute Viral Tonsillitis in Children

CONTEXT: Acute viral tonsillitis is a common childhood condition, and high-quality randomized evidence on the efficacy of individualized homeopathic medicines (IHMs) remains limited. OBJECTIVE: To evaluate the efficacy and clinical utility of IHMs in children with acute viral tonsillitis. DESIGN: Double-blind, randomized (2:1), placebo-controlled clinical trial. SETTING: Single-center outpatient pediatric clinical setting. SUBJECTS: Seventy-eight children with acute viral tonsillitis were enrolled and randomized. INTERVENTIONS: Participants received IHMs prescribed according to a classical individualized approach or a matching placebo, in addition to standard supportive care. MAIN OUTCOME MEASURES: The primary outcome was longitudinal change in the Tonsillopharyngitis assessment (TPA) score. Secondary outcomes were the Sore Throat Pain Intensity Scale, Difficulty in Swallowing Score, and Swelling of Tonsils Score. Time to sore throat remission and complete clinical recovery (CCR) were also assessed. RESULTS: was the most frequently prescribed remedy and also showed the most consistent and clinically meaningful improvement across all outcome measures.