Neurological Effects of Cleistocalyx nervosum var. paniala Berry on Hippocampal Transcriptome, Neuritogenesis, and Synaptogenesis
CNP extract alters transcriptional networks and enhances neurite outgrowth in primary hippocampal neurons in a sex-dependent manner, with male-biased effects on Syn1-Psd95 colocalization. These findings support further dose-response, mechanistic, and sex-stratified in vivo studies to evaluate its neurobiological potential.
Authors
- Waluga Plaingam
- Thanit Saeliw (ORCID: https://orcid.org/0009-0009-9047-3197)
- Songphon Kanlayaprasit (ORCID: https://orcid.org/0000-0002-4367-3622)
- Thanawin Jantheang (ORCID: https://orcid.org/0009-0007-9427-4211)
- Somsri Charoenkiatkul (ORCID: https://orcid.org/0000-0002-0855-8442)
- Pawinee Panjabud (ORCID: https://orcid.org/0009-0001-8240-3502)
- Pattanachat Lertpeerapan (ORCID: https://orcid.org/0009-0007-3809-6713)
- Monruedee Sukprasansap (ORCID: https://orcid.org/0000-0003-0205-7337)
- Tewin Tencomnao (ORCID: https://orcid.org/0000-0003-4177-2165)
- Kasidit Kasitipradit (ORCID: https://orcid.org/0009-0000-7330-6631)
- Tewarit Sarachana (ORCID: https://orcid.org/0000-0003-4518-9399)
- Valerie Wailin Hu (ORCID: https://orcid.org/0000-0002-3357-0777)
- Chawanphat Muangnoi
- Chayanit Poolcharoen
- Worratha Parnich (ORCID: https://orcid.org/0009-0008-2404-1137)
Institutions
- Chulalongkorn University (TH)
- George Washington University (US)
- Mahidol University (TH)
- Rangsit University (TH)
Publication Details
- Journal
- Nutrients
- Published
- 2026-04-10
- DOI
- https://doi.org/10.3390/nu18081200
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mahidol University
- National Research Council of Thailand