Preventive Effect of Caffeic Acid Phenethyl Ester, an Active Component of Propolis, against TNF-α-Induced Endothelial Dysfunction through the β2-Adrenoceptor-Mediated eNOS/NO Signal Pathway
studies using aortic rings further validated that CAPE stimulates eNOS activation and NO production via β2AR/Gαs signaling. Collectively, these findings indicate that CAPE enhances endothelial function and exerts anti-inflammatory effects through the β2AR-mediated signaling, highlighting its potential as a therapeutic candidate for endothelial dysfunction and inflammation-related cardiovascular diseases.
Authors
- Hwi‐yeol Yun (ORCID: https://orcid.org/0000-0001-8793-2449)
- Jueson Maeng
- Eun Hee Han (ORCID: https://orcid.org/0000-0002-0137-0156)
- Hye Gwang Jeong (ORCID: https://orcid.org/0000-0002-8020-8914)
- Jin Song Park (ORCID: https://orcid.org/0009-0001-8039-0736)
- Anh Thi Ngoc Bui
- Seung-Hwa Baek
- Gi Ho Lee
Institutions
- Biocon (Switzerland) (CH)
- Chungnam National University (KR)
- Korea Basic Science Institute (KR)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-04-10
- DOI
- https://doi.org/10.1021/acs.jafc.5c15918
- Citations
- 1
- Primary Topic
- Bee Products Chemical Analysis
- Type
- article
- Field-Weighted Citation Impact
- 21.71
Funders
- National Research Foundation of Korea