Exercise in Hypoxic Environments: An Overview of Systematic Reviews on Performance, Physiological Adaptation, and Clinical Implications

Exercise under hypoxic conditions may enhances aerobic and hematological adaptations in trained populations, whereas acute exposure tends to impair performance and entails clinical risks. However, given the restricted search strategy, substantial heterogeneity, lack of formal overlap quantification, and the predominance of low methodological quality reviews, these findings should be interpreted with caution. Evidence on metabolic benefits remains limited, highlighting the need for further high-quality systematic reviews and meta-analyses to clarify optimal hypoxic training protocols and outcomes.

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Journal
Sports
Published
2026-04-10
DOI
https://doi.org/10.3390/sports14040147
Primary Topic
High Altitude and Hypoxia
Type
article
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article

Exercise in Hypoxic Environments: An Overview of Systematic Reviews on Performance, Physiological Adaptation, and Clinical Implications

Eduardo Pena, Lissé Angarita, Héctor Fuentes-Barría, Cherie Flores-Fernández et al.
Sports
High Altitude and Hypoxia
article

Exercise in Hypoxic Environments: An Overview of Systematic Reviews on Performance, Physiological Adaptation, and Clinical Implications

Eduardo Pena, Lissé Angarita, Héctor Fuentes-Barría, Cherie Flores-Fernández, Samia El Alam, Raul Alberto Aguilera-Eguía, Míguel Alarcón-Rivera
article en

Abstract

Exercise under hypoxic conditions may enhances aerobic and hematological adaptations in trained populations, whereas acute exposure tends to impair performance and entails clinical risks. However, given the restricted search strategy, substantial heterogeneity, lack of formal overlap quantification, and the predominance of low methodological quality reviews, these findings should be interpreted with caution. Evidence on metabolic benefits remains limited, highlighting the need for further high-quality systematic reviews and meta-analyses to clarify optimal hypoxic training protocols and outcomes.

SportsVol. 14(4)
Universidad Andrés Bello (CL), Universidad Católica de la Santísima Concepción (CL), Universidad Santo Tomás (CL), Metropolitan University of Technology (CL), Arturo Prat University (CL)
Openalex Percentile: Top 25%
High Altitude and Hypoxia
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Exercise in Hypoxic Environments: An Overview of Systematic Reviews on Performance, Physiological Adaptation, and Clinical Implications — Eduardo Pena, Lissé Angarita, et al. · Sports (2026) | TGRS Research Map | TGRS