Soybean oil and leucine in late gestation and lactation improve maternal and offspring lipid metabolism and insulin sensitivity: insights from pig model

Introduction: Lipid metabolism is crucial for the development of insulin resistance. Leucine supplementation enhances insulin sensitivity and lipid metabolism. Soybean oil has the potential to improve insulin sensitivity. A comprehensive investigation of the effects and potential mechanisms of leucine and soybean oil supplementation is warranted. This study aims to investigate the effects and underlying mechanisms of maternal soybean oil and leucine intake on lipid metabolism, insulin sensitivity in both dams and offspring. Materials and methods: = 17). The experimental was designed as a 2 × 2 factorial arrangement, which included the level of soybean oil (crude fat 5% or 10%) and leucine (0 or 1%) in the diet. Results: ). Discussion: Our study provides evidence that dietary supplementation with soybean oil and leucine affects offspring growth by modulating lipid metabolism and insulin sensitivity in sows and pigs, and by altering intestinal microbiota.