Multilevel Residual Complexity Analysis Reveals Origin of Nanomolar Antiviral Bioactives of “Isoquercitrin”
) also prevented EBOV infection of Vero E6 cells, supporting the conclusion that the dicitriosides inherit the promising potential of IQC90 as antiviral leads for clinical translation. Ultrahigh field 1.1 GHz NMR spectroscopy, particularly 1D selective TOCSY experiments and nuclear genotyping via quantum-mechanical spin analysis, enabled structure elucidation and provided definitive reference points for the dicitriosides as complex oligoglycoside esters.
Authors
- Michel Chrétien (ORCID: https://orcid.org/0000-0002-8588-4460)
- Guido F. Pauli (ORCID: https://orcid.org/0000-0003-1022-4326)
- Annie V. Roy (ORCID: https://orcid.org/0000-0001-5754-3514)
- Logan Banadyga (ORCID: https://orcid.org/0000-0001-8390-2648)
- Majambu Mbikay (ORCID: https://orcid.org/0000-0003-4854-6507)
- Wenjun Zhu (ORCID: https://orcid.org/0000-0002-6579-9891)
- Ye Liu (ORCID: https://orcid.org/0000-0003-3273-8459)
- Daniela Rebollar-Ramos (ORCID: https://orcid.org/0000-0002-7720-6360)
- James McAlpine
- Shao-Nong Chen
- J. Brent Friesen (ORCID: https://orcid.org/0000-0002-0739-9224)
- Guy Harris
- Michael Chan
- Shihua He
Institutions
- Public Health Agency of Canada (CA)
- Dominican University (US)
- University of Illinois Chicago (US)
- Pharmac (NZ)
- Montreal Clinical Research Institute (CA)
- University of Manitoba (CA)
- Unisys (United States) (US)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2026-04-10
- DOI
- https://doi.org/10.1021/acs.jnatprod.6c00077
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Public Health Agency of Canada
- National Institute of General Medical Sciences