Rapid Response, Unexpected Risk: A ROS1-Positive Non-Small Cell Lung Cancer (NSCLC) Case with Lazarus Syndrome and Fatal Thrombosis

A 57-year-old woman with a ROS1-rearranged NSCLC patient demonstrated a Lazarus response to crizotinib but later developed recurrent pulmonary embolism (PE) with right ventricular (RV) failure. This incident highlights the potential crizotinib-related thrombotic risk and the need for appropriate monitoring of vascular complications, particularly in limited-option settings such as Thailand.

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Publication Details

Journal
Asian Medical Journal and Alternative Medicine
Published
2026-04-10
DOI
https://doi.org/10.70933/2773-9465.1331
Primary Topic
Chronic Lymphocytic Leukemia Research
Type
article
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article

Rapid Response, Unexpected Risk: A ROS1-Positive Non-Small Cell Lung Cancer (NSCLC) Case with Lazarus Syndrome and Fatal Thrombosis

P. Eiamprapaporn, Piraya Patrathiranond, Sasipim Thitvirachawat
Asian Medical Journal and Alternative Medicine
Chronic Lymphocytic Leukemia Research
article

Rapid Response, Unexpected Risk: A ROS1-Positive Non-Small Cell Lung Cancer (NSCLC) Case with Lazarus Syndrome and Fatal Thrombosis

P. Eiamprapaporn, Piraya Patrathiranond, Sasipim Thitvirachawat
article en

Abstract

A 57-year-old woman with a ROS1-rearranged NSCLC patient demonstrated a Lazarus response to crizotinib but later developed recurrent pulmonary embolism (PE) with right ventricular (RV) failure. This incident highlights the potential crizotinib-related thrombotic risk and the need for appropriate monitoring of vascular complications, particularly in limited-option settings such as Thailand.

Asian Medical Journal and Alternative MedicineVol. 26(1)
Thammasat University Hospital (TH)
Good health and well-being
Openalex Percentile: Top 5%
Chronic Lymphocytic Leukemia Research
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