Synthesis and Preclinical Evaluation of <sup>68</sup> Ga-Labeled Radiotracers for Monitoring PD-L1 Expression in Tumors
Ga]Ga-PEG-PRO-ZB can effectively visualize PD-L1 expression in vivo, offering valuable insights into the rational design and optimization of small-molecule based PD-L1 radiotracers.
Authors
- Kexia Fang
- Bo Zhou (ORCID: https://orcid.org/0000-0003-2515-4367)
- Feng Gao (ORCID: https://orcid.org/0000-0002-8792-6257)
- Yinlong Zhao
- Xue Shang
- Yuan Pan
- Xiaoli Zhang
- Min Li
Institutions
- Shandong University (CN)
- Ministry of Education (KR)
- 82th Hospital of Pla (CN)
- Second Affiliated Hospital of Jilin University (CN)
- Central Hospital of Zibo (CN)
- Qilu Hospital of Shandong University (CN)
- 458th Hospital PLA (CN)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-10
- DOI
- https://doi.org/10.1021/acs.jmedchem.5c03587
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- National Science and Technology Major Project