The prevalence and etiology of macro-growth hormone (GH)

OBJECTIVES: Several macro-hormones have been reported to date. Among them, macroprolactinemia is a common cause of hyperprolactinemia. Growth hormone (GH) and prolactin (PRL) are anterior pituitary hormones related by structure and function. The aim of this study was to clarify the prevalence and etiology of macro-GH. METHODS: I-GH tracers were performed to examine the nature of macro-GH. RESULTS: for 20-kDa GH. CONCLUSIONS: We presented a patient with macro-GH due to anti-human GH autoantibody. The prevalence of macro-GH was extremely rare compared to that of macro-PRL.