1,2,3‐Triazole Isonicotinate/Nicotinate Derivatives as Cholinesterase and α‐Amylase Inhibitors: Synthesis, Enzyme Inhibition, Antioxidant Activity, and Molecular Docking Studies

= 7.76±0.09 µM), outperforming standard inhibitors. Compound 3c exhibited very good antioxidant activity using DPPH and ABTS radical scavenging tests. Molecular docking studies supported the experimental findings, demonstrating appropriate binding energies and essential hydrogen bonds and π-π interactions at the active sites of the target enzymes. Computerized ADME analysis showed promising pharmacokinetic properties, including high gastrointestinal absorption and blood-brain barrier permeability.