Evaluation of the Phenolic Profile, Antioxidant, and Anti‐Gout Effects of Three Aerial Parts of the Algerian Herb <i>Diplotaxis harra</i>
of 0.212 mg/mL, comparable to that of the positive control allopurinol (0.25 mg/mL). Consistently, molecular docking showed that gentisic and protocatechuic acids, most phenolics in the extract, bind XO with more favorable energies than allopurinol through extensive hydrogen-bonding and hydrophobic interactions at key active site residues. Overall, this initial organ-specific evaluation of D. harra provides strong support for its flower extracts as promising candidates for standardized anti-gout preparations and as scaffolds for future XO inhibitor development.
Authors
- Mustafa Abdullah Yılmaz (ORCID: https://orcid.org/0000-0002-4090-7227)
- ABBAS TARHAN
- Salah Akkal (ORCID: https://orcid.org/0000-0002-4999-5673)
- Mohamed Badreddine Mokhtarı (ORCID: https://orcid.org/0000-0003-3066-8346)
- El Hassen Mokrani (ORCID: https://orcid.org/0000-0002-2725-2940)
- Khellaf Rebbas (ORCID: https://orcid.org/0000-0002-2846-3838)
- Abdelkader Slimani
- Gökhan Zengin (ORCID: https://orcid.org/0000-0001-6548-7823)
- Asma Mosbah
- Chawki Bensouici
- Mohamed Yahia Zeriab Badaoui
- Oguz Cakir
- Mahrouk Abdelkader
Institutions
- Dicle University (TR)
- University Frères Mentouri Constantine 1 (DZ)
- Selçuk University (TR)
- Biotechnology Research Center (IR)
- University Mohamed Boudiaf of M'sila (DZ)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/cbdv.202503139
- Citations
- 1
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 19.44