Long-term risk of renal impairment after complete primary repair of classic bladder exstrophy

Background: This study evaluated the long-term risk of renal impairment and the factors influencing renal function after complete primary repair of classic bladder exstrophy (CBE). Materials and Methods: = 66, effect size = 0.5) showed a power of 0.98. The primary outcome was the estimated glomerular filtration rate (eGFR) at the final follow-up, with renal impairment defined as < 60 mL/min/1.73 m². Univariate and multivariate analyses assessed associations between renal impairment and key clinical factors. Results: = 0.033; OR 6.34) as independent predictors. Conclusions: Long-term renal function remained stable in most patients after complete primary repair of CBE, although 6% experienced renal impairment. Severe hydronephrosis, high-grade reflux, febrile UTI, and reduced bladder capacity were essential predictors, emphasizing the need for close monitoring and timely management.