Xanthenone Orchestrates the Renin–Angiotensin System/Ferroptosis Crosstalk: A Novel AT2R‐Dependent Strategy Against Lower Limb Transient Ischemia‐Induced Liver Injury

, and ferritin accumulation, while modulating the ferritinophagy axis through upregulation of HERC2 and suppression of NCOA4. These effects were largely abolished by PD123319, indicating AT2R dependency. In conclusion, XNT protects against LLTI-induced hepatic injury by orchestrating a dual antioxidant and anti-ferroptotic response via the Ang-(1-9)/AT2R axis. These findings unveil a novel crosstalk between RAS modulation and ferroptosis regulation, positioning AT2R activation as a promising therapeutic strategy for ischemia/reperfusion-related liver damage.