Deoxy-Piezo1 hyperactivity elevates pump-leak fluxes and lactate production in sickle cells
fluxes were found to be substantially increased above those in normal, oxy, or deoxy RBCs or in oxy sickle RBCs. These results opened the possibility that pump-mediated increased ATP turnover in deoxy sickle cells contributes significantly to lactate production and metabolic acidosis in sickle cell disease.
Authors
- Virgilio L. Lew (ORCID: https://orcid.org/0000-0002-0554-2701)
- Simon D. Rogers
Institutions
- Physiological Society (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- Biophysical Journal
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.bpj.2026.04.008
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Haematology, School of Clinical Medicine, University of Cambridge