Comparative Study of Subcutaneous 6-Month Versus Intramuscular 3-Month Leuprorelin Use in Central Precocious Puberty

=0.03). Luteinizing hormone levels were reduced in all groups, with random luteinizing hormone levels remaining below 0.6 IU/L. Luteinizing hormone values 2 hours after gonadotropin-releasing hormone analogue administration showed a more homogeneous suppressive effect in group 1. Mild to moderate pain was present in both groups, but higher in group 1. Scores for acceptance, easiness and satisfaction were similar between groups.Six month subcutaneous leuprorelin deaccelerated bone age, preserving the predicted final height in a manner similar to 3-month intramuscular leuprorelin. Only 6-month subcutaneous leuprorelin could reduce uterine and breast volumes. Pain was more prominent with six-month subcutaneous leuprorelin, and drug deposition in the subcutaneous tissue was identified more frequently, without an inflammatory process or a risk of therapeutic failure.