Isolation, Structural Elucidation, and Biological Evaluation of Homoisoflavonoids From <i>Pterolobium Macropterum</i>

of 1.08 µM, and potently inhibited the colony formation of JIMT-1 cells at 2.0 µM. Furthermore, compounds 11 and 12 (MIC = 32 µg/mL) exhibited broad-spectrum antibacterial activity against the abovementioned bacterial strains by regulating the ROS level. Preliminary structure-activity relationship (SAR) analysis of these homoisoflavonoids revealed that the α,β-unsaturated moieties are crucial for both anti-proliferative and antibacterial activities.