Multifunctional eutectogel for co-delivery of baicalein and metformin to promote diabetic wound healing

, and excellent DPPH radical scavenging capacity. In the diabetic rat wound model, Bai-Met/DES-Gel effectively accelerated wound healing by inhibiting inflammatory responses, promoting granulation tissue formation, facilitating collagen alignment, stimulating angiogenesis, and enhancing cell proliferation. This study advanced the potential application of DES on co-delivery of natural and synthetic drugs, while providing a novel solution for the treatment of diabetic wounds.