The role of S100A8/A9 in the pathogenesis of acute exacerbations of pulmonary fibrosis
During acute exacerbation of idiopathic interstitial pneumonia, bronchoalveolar lavage fluid (BALF) and serum S100A8/A9 levels were elevated and associated with poor prognosis. In a mouse model of acute pulmonary fibrosis exacerbation, therapeutic targeting of S100A8/A9 attenuated lung inflammation and fibrosis, accompanied by reduced S100A8/A9 levels and neutrophil extracellular traps within airways. In vitro experiments demonstrated that neutrophil-derived S100A8/A9 promoted activation of lung fibroblasts and their differentiation into myofibroblasts, which was effectively inhibited by neutralizing antibodies.
Authors
- Nobuaki Miyahara (ORCID: https://orcid.org/0000-0002-8616-0886)
- Nahoko Tomonobu (ORCID: https://orcid.org/0000-0002-1121-3912)
- Masakiyo Sakaguchi (ORCID: https://orcid.org/0000-0002-0566-4872)
- Taichi Ozeki
- Satoru Senoo (ORCID: https://orcid.org/0000-0001-7506-2247)
- Rie Kinoshita (ORCID: https://orcid.org/0000-0003-1977-7920)
- Akihiko Taniguchi (ORCID: https://orcid.org/0000-0002-1170-1123)
- Ryota Sunami
- Hisao Higo (ORCID: https://orcid.org/0000-0003-4946-0123)
- Junko Itano
- Yumi Inukai (ORCID: https://orcid.org/0000-0002-0635-1376)
- Yoshinobu Maeda
- Naoki Nakamura (ORCID: https://orcid.org/0000-0003-1728-5658)
- Ayaka Tanaka (ORCID: https://orcid.org/0009-0004-6849-5895)
Institutions
- Okayama University of Science (JP)
- Okayama University (JP)
- Junshin Gakuen University (JP)
- Kurashiki Central Hospital (JP)
- Okayama University Hospital (JP)
- Fukuyama Cardiovascular Hospital (JP)
- National Hospital Organization (JP)
Publication Details
- Journal
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Published
- 2026-04-11
- DOI
- https://doi.org/10.1152/ajplung.00162.2025
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japan Science and Technology Agency