Preventing Mother to Child Transmission of Human Immunodeficiency Virus: 20‐Year Trends in Management and Clinical Practice in a French Hospital – A Retrospective Observational Study

Background and Aims: Since the discovery of human immunodeficiency virus (HIV) mother to child transmission (MTCT), its prevention has been a priority. Guideline adherence has drastically reduced MTCT, virtually inexistent today in high-income countries. Methods: test, and Cochran-Armitage test were used when appropriate. Results: < 0.01). Approximately 98% of newborns received antiretroviral prophylaxis at discharge, and 91.3% of infants had at least 6 months of follow-up. We observed only one case of MTCT in 2000. Conclusion: Our study illustrates the major changes for the prevention of HIV MTCT. Our findings highlight how early and effective triple ART led to better obstetrical outcomes requiring fewer medical interventions. Thorough treatment, aligned with national guidelines, can virtually eliminate MTCT, serving as a model for global practice.