Epithelial barrier DUOX2 serves as early immune defense in intestinal pathogen control
bursts in the vicinity of the pathogen during early, but not late, stages of infection. In vivo, epithelial DUOX2 acted as universal immune defense system without inducing or perpetuating intestinal inflammation. Our findings show that epithelial DUOX2 chemically undermines pathogen-induced niches, decreasing bacterial virulence and strengthening the barrier.
Authors
- Ulla G. Knaus (ORCID: https://orcid.org/0000-0002-7375-0385)
- Vincent P. Kelly (ORCID: https://orcid.org/0000-0001-7067-5407)
- Suisheng Zhang
- Maurice O’Mara
- Claire Fergus (ORCID: https://orcid.org/0009-0000-9081-1736)
Institutions
- University College Dublin (IE)
- Trinity College Dublin (IE)
Publication Details
- Journal
- Mucosal Immunology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.mucimm.2026.04.004
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science Foundation Ireland