Synaptic density imaging in behavioral variant frontotemporal dementia: A comparison of <sup>1</sup> <sup>8</sup> F‐SynVesT‐1 and <sup>1</sup> <sup>8</sup> F‐FDG PET
INTRODUCTION: F-FDG) PET might improve diagnostic accuracy and disease monitoring in bvFTD. METHODS: F-FDG PET in 10 patients with bvFTD and 10 age-matched healthy controls. RESULTS: F-FDG PET. SV2A binding in the frontal cortex and insula significantly correlated with the Frontal Assessment Battery scores. DISCUSSION: F-FDG PET. SV2A imaging demonstrates considerable promise as a new in vivo biomarker for bvFTD.
Authors
- Jean‐Dominique Gallezot (ORCID: https://orcid.org/0000-0003-0399-8374)
- Nabeel Nabulsi (ORCID: https://orcid.org/0000-0001-8129-0051)
- Faranak Ebrahimian Sadabad (ORCID: https://orcid.org/0000-0002-6649-7211)
- Yanghong Yang (ORCID: https://orcid.org/0000-0002-6816-1252)
- Takuya Toyonaga (ORCID: https://orcid.org/0000-0002-0369-8294)
- Waleed Ibrahim (ORCID: https://orcid.org/0000-0001-9640-4090)
- Arman Fesharaki‐Zadeh (ORCID: https://orcid.org/0000-0002-8294-7163)
- Mika Naganawa (ORCID: https://orcid.org/0000-0002-4408-2621)
- Brian Pittman (ORCID: https://orcid.org/0000-0002-0353-5604)
- Adam P. Mecca (ORCID: https://orcid.org/0000-0003-1982-5443)
- Yanjun Wu
- Ryan S O'Dell
- Salih Cayir
- Richard E. Carson
- David Matuskey
- Stephen Strittmatter
- Christopher H. van Dyck
Institutions
- SUNY Downstate Health Sciences University (US)
- Yale University (US)
- Marshall University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/alz.71283
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Yale University
- National Institutes of Health