Single‐Cell Profiling Reveals <scp>RAB13</scp> <sup>+</sup> Endothelial Cells and Profibrotic Mesenchymal Cells in Aged Human Bone Marrow
profibrotic cells absent in younger individuals. Finally, immunofluorescent imaging and spatial transcriptomics confirmed the presence of these aging-associated cells in BM samples from aged individuals. In summary, this work provides a comprehensive view of the transcriptional landscape, cellular interactions, and spatial organization of aged EC and MSC, offering novel insights and potential targets that could be exploited for preventing age-associated changes in humans.
Authors
- Marta Abengózar (ORCID: https://orcid.org/0000-0003-3117-1884)
- Marta Miñana Barrios
- Emma Muiños‐López
- Miguel Cócera (ORCID: https://orcid.org/0000-0002-5679-1206)
- Robert Lehmann (ORCID: https://orcid.org/0000-0001-7071-4226)
- Purificación Ripalda‐Cemboráin (ORCID: https://orcid.org/0000-0001-8425-3563)
- Delia Quilez Agreda
- Diego Alignani (ORCID: https://orcid.org/0000-0003-0241-1375)
- Luis‐Esteban Tamariz‐Amador (ORCID: https://orcid.org/0000-0002-4088-0992)
- Jesper Tegnér (ORCID: https://orcid.org/0000-0002-9568-5588)
- S. Sarvide
- Paula Aguirre‐Ruiz (ORCID: https://orcid.org/0000-0002-5871-372X)
- Patxi San Martín‐Úriz (ORCID: https://orcid.org/0000-0003-1483-4279)
- Itziar Cenzano (ORCID: https://orcid.org/0000-0002-9030-3069)
- David Gomez‐Cabrero
- Amaia Vilas‐Zornoza (ORCID: https://orcid.org/0000-0001-6693-0989)
- Borja Sáez (ORCID: https://orcid.org/0000-0001-7908-7089)
- Isabel A. Calvo (ORCID: https://orcid.org/0000-0001-6619-4571)
- Jin Ye (ORCID: https://orcid.org/0000-0002-7430-3915)
- Aitziber Lopez Lopez
- Felipe Prósper
- Javier Ruiz
- Álvaro Lopez‐Janeiro
- Laura Sudupe
- Lorea Campos‐Dopazo
- Ignacio Sancho
- Ana Rosa Lopez‐Perez
Institutions
- Karolinska University Hospital (SE)
- Science for Life Laboratory (SE)
- Navarre Institute of Health Research (ES)
- Navarrabiomed (ES)
- Hospital Universitario Reina Sofía (ES)
- Clinica Universidad de Navarra (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- King Abdullah University of Science and Technology (SA)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Aging Cell
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1111/acel.70475
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Universidad de Navarra
- Ministerio de Ciencia e Innovación
- Centro de Investigación Biomédica en Red de Cáncer
- Gobierno de Navarra
- Horizon 2020 Framework Programme
- Instituto de Salud Carlos III
- European Regional Development Fund