Determination of Folate Bioavailability From Brewer's Yeast in a Dual Isotope Randomized Human Intervention Study
-labeled (6S)-5-methyltetrahydrofolate as quantitation standard in stable isotope dilution assays. The main outcome of the study was that the yeast folates revealed for the five assessed volunteers a mean bioavailability of 74 % relative to 5-methyltetrahydrofolate as the reference dose. The study allows to conclude that intrinsically labeled foods are best suited to accurately measure the bioavailabilities of natural food folates embedded in their natural food matrix.
Authors
- Jean-Pierre Knapp
- Nadine Weber (ORCID: https://orcid.org/0000-0002-0566-6181)
- Thomas Skurk (ORCID: https://orcid.org/0000-0002-6875-1658)
- Lisa Striegel (ORCID: https://orcid.org/0000-0002-2028-7884)
- Michael Rychlik (ORCID: https://orcid.org/0000-0002-5826-6288)
- Yvonne Methner (ORCID: https://orcid.org/0000-0002-7489-9333)
- Viola Groehn
- Beate Brandl (ORCID: https://orcid.org/0000-0002-9328-8108)
Institutions
- The University of Queensland (AU)
- TUM Klinikum (DE)
- Weihenstephan-Triesdorf University of Applied Sciences (DE)
- Merck Serono S.A. (Switzerland) (CH)
- Leibniz-Institute for Food Systems Biology at the Technical University of Munich (DE)
- ARC Centre of Excellence for Plant Success in Nature and Agriculture (AU)
- Technical University of Munich (DE)
Publication Details
- Journal
- Molecular Nutrition & Food Research
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/mnfr.70453
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00