Oncolytic adenovirus in combination with PD-L1-targeted radioimmunotherapy exerts synergistic antitumor effect against pancreatic cancer
BACKGROUND: To date, no radioimmunotherapy (RIT) regimen has been approved by US Food and Drug Administration for the treatment of pancreatic cancers. Highly desmoplastic and immune-desert phenotypes of pancreatic cancer remain two major hurdles that attenuate the efficacy of conventional treatment (radiotherapy and chemotherapy) and immunotherapeutic (immune checkpoint inhibitors and chimeric antigen receptor T cells). METHOD: Lu-aPD-L1)). RESULTS: T cells over the respective monotherapy. CONCLUSION: Lu-aPD-L1 in a multifaceted manner to elicit synergistic antitumor immune response against desmoplastic and poorly immunogenic pancreatic tumors.
Authors
- Jeongwon Lee (ORCID: https://orcid.org/0000-0002-2353-2603)
- Jeemin Seo
- Hyeju Jeong
- Ji Soo Yi (ORCID: https://orcid.org/0000-0002-7545-3878)
- Jinwoo Hong (ORCID: https://orcid.org/0000-0001-8647-9953)
- Chae‐Ok Yun (ORCID: https://orcid.org/0000-0002-9466-4531)
- In-Wook Kim (ORCID: https://orcid.org/0000-0002-8394-6613)
- Javeria Zaheer (ORCID: https://orcid.org/0000-0002-1418-1047)
- Joycie Shanmugiah
- Ju Hee Kim (ORCID: https://orcid.org/0000-0002-4945-0753)
- Arum R. Yoon (ORCID: https://orcid.org/0000-0002-9595-3204)
- Seungyoun Kim
- Hyeongi Kim (ORCID: https://orcid.org/0000-0001-6990-3900)
Institutions
- Korea Institute of Radiological and Medical Sciences (KR)
- Hanyang University (KR)
- Korea Institute of Science and Technology (KR)
- Korea University of Science and Technology (KR)
- Anyang University (KR)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1136/jitc-2025-014508
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Ministry of Food and Drug Safety
- Korea Health Industry Development Institute
- Korea Basic Science Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea