Development and Synthesis of Bioactive (3‐Arylediene‐1‐phenyl‐1 <i>H</i> ‐pyrazol‐4‐yl)acryloyl‐4‐hydroxy‐6‐methyl‐2 <i>H</i> ‐pyran‐2‐ones With Anti‐Malarial and Anti‐Inflammatory Activities
values of 7.05 ± 0.17 µM and 0.95 ± 0.06 µM, respectively. Docking studies revealed strong binding affinities and favorable molecular interactions, supporting the observed bioactivities. This study highlights chalcone-pyrazole hybrids as promising therapeutic scaffolds. In particular, compound 3c emerges as a compelling lead candidate for further optimization and preclinical investigation as a dual-action agent against malaria and inflammation.
Authors
- Sudeep Dhillon (ORCID: https://orcid.org/0009-0001-3463-0030)
- Binesh Kumar (ORCID: https://orcid.org/0000-0002-3760-9974)
- Mayank Kinger (ORCID: https://orcid.org/0000-0002-4269-0834)
- Deepak Kumar Aneja (ORCID: https://orcid.org/0000-0003-3901-0487)
- Ginna Kumari (ORCID: https://orcid.org/0009-0007-2677-6260)
- Mamta Chahal (ORCID: https://orcid.org/0009-0003-3170-289X)
- Priyanka Rani (ORCID: https://orcid.org/0009-0003-0852-6170)
- Jai Devi
Institutions
- Chaudhary Devi Lal University (IN)
- Guru Jambheshwar University of Science and Technology (IN)
Publication Details
- Journal
- Archiv der Pharmazie
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/ardp.70231
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Council of Scientific and Industrial Research, India