Circular RNA signatures associated with nanoplastics-induced healthspan alterations in C. elegans

BACKGROUND: Nanoplastics have emerged as ubiquitous environmental contaminants with the capacity to perturb diverse biological processes, including organismal aging. However, the molecular underpinnings connecting nanoplastic exposure to healthspan modulation remain largely unknown. RESULTS: exposure. CONCLUSIONS: Early-life nanoplastic exposure disrupts healthspan through persistent transcriptional and circRNA alterations that recapitulate molecular signatures characteristic of physiological aging. These findings highlight circRNA dysregulation as a sensitive biomarker for nanoplastics-induced healthspan impairment and provide new insights into how environmental nanoplastics influence aging processes.