Non–Small Cell Lung Cancer, Version 4.2026, NCCN Clinical Practice Guidelines In Oncology
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Non-Small Cell Lung Cancer (NSCLC) provide recommendations for the treatment of patients with NSCLC, including diagnosis, primary disease management, surveillance, and subsequent treatment. The panel has updated the list of recommended targeted therapies based on recent FDA approvals and clinical data. This selection from the NCCN Guidelines for NSCLC focuses on treatment recommendations for advanced or metastatic NSCLC with actionable biomarkers.
Authors
- Jane Yanagawa
- Lisa E. Hang
- Jules Lin (ORCID: https://orcid.org/0000-0003-4733-0659)
- Karen Yun (ORCID: https://orcid.org/0000-0003-1916-2176)
- Andrea L. Axtell (ORCID: https://orcid.org/0000-0003-0916-3327)
- Jessica R. Bauman (ORCID: https://orcid.org/0000-0001-8691-0387)
- Rudy P. Lackner
- Tawee Tanvetyanon (ORCID: https://orcid.org/0000-0002-1287-1757)
- B. Levy
- A. Bharat
- Daniel Morgensztern (ORCID: https://orcid.org/0000-0003-4349-2028)
- Ana Lucia Ruano Mendez
- Patricio Marcelo Polanco (ORCID: https://orcid.org/0000-0002-1719-1208)
- Travis E. Grotz (ORCID: https://orcid.org/0000-0002-7753-097X)
- Trey C. Mullikin (ORCID: https://orcid.org/0000-0002-1099-1763)
- Douglas E. Wood (ORCID: https://orcid.org/0000-0002-1396-7005)
- Dara L. Aisner (ORCID: https://orcid.org/0000-0001-5203-5932)
- Matthew A. Gubens (ORCID: https://orcid.org/0000-0002-6482-1954)
- Gregory J. Riely (ORCID: https://orcid.org/0000-0001-5357-4313)
- Michael Lanuti (ORCID: https://orcid.org/0000-0001-6049-1276)
- Christine M. Lovly (ORCID: https://orcid.org/0000-0002-3641-6361)
- A. Tam
- Edwin H. Yau (ORCID: https://orcid.org/0000-0002-3972-0756)
- Theresa A. Shapiro (ORCID: https://orcid.org/0000-0002-6823-7536)
- Jonathan Wesley Riess (ORCID: https://orcid.org/0000-0001-7370-7304)
- Thomas J. Dilling (ORCID: https://orcid.org/0000-0003-0257-6989)
- Dwight Hall Owen (ORCID: https://orcid.org/0000-0002-6598-4886)
- Jonathan E. Dowell (ORCID: https://orcid.org/0000-0002-0202-9697)
- Dawn Owen
- Gregory A. Durm
- James P. Stevenson
- Aditya Juloori (ORCID: https://orcid.org/0000-0002-7486-6208)
- S. Gettinger
- Fabien Maldonado
- Tejas Patil
- Aakash Desai
- Billy W. Loo
- Aditi P. Singh
- Kristina Gregory
- Thomas Ng
Institutions
- Fox Chase Cancer Center (US)
- Roswell Park Comprehensive Cancer Center (US)
- Barnes-Jewish Hospital (US)
- Cleveland Clinic (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Tennessee Health Science Center (US)
- Breast Cancer Research Foundation (US)
- University of Utah (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- UC San Diego Health System (US)
- Huntsman Cancer Institute (US)
- Cancer Institute (WIA) (IN)
- Susan Thompson Buffett Foundation (US)
- WinnMed (US)
- Yale Cancer Center (US)
- Moffitt Cancer Center (US)
- Massachusetts General Hospital (US)
- Fred Hutch Cancer Center (US)
- Southwestern Medical Center (US)
- Jewish Hospital (US)
- University of Wisconsin Carbone Cancer Center (US)
- Sidney Kimmel Cancer Center (US)
- University Hospitals Seidman Cancer Center (US)
- Duke Medical Center (US)
- University of Colorado Cancer Center (US)
- Smilow Cancer Hospital (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center
- Moores Cancer Center
- University of Chicago Medicine Comprehensive Cancer Center
- UCLA Jonsson Comprehensive Cancer Center
- Vanderbilt-Ingram Cancer Center
- Stanford Cancer Institute
- Duke Cancer Institute
- Fred and Pamela Buffett Cancer Center
- UC Davis Comprehensive Cancer Center
- Harold C. Simmons Comprehensive Cancer Center
- O'Neal Comprehensive Cancer Center
- National Comprehensive Cancer Network
- Indiana University (US)
- University of Pennsylvania (US)
- University of California, Davis (US)
- The University of Texas Southwestern Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of the National Comprehensive Cancer Network
- Published
- 2026-04-01
- DOI
- https://doi.org/10.6004/jnccn.2026.0017
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00