Amelioration of Diabetic Dyslipidaemia by an Aqueous Extract of Tremella fuciformis in Streptozotocin-Induced Diabetic Mice

Diabetic dyslipidaemia is a major contributor to cardiovascular risk in insulin-deficient states. This study evaluated the hypolipidemic activity of an aqueous extract of Tremella fuciformis (AETF) in streptozotocin (STZ)-induced diabetic mice. Male BALBc mice were rendered diabetic by a single intraperitoneal injection of STZ at a dose of 60 mgkg body weight. Hyperglycaemic animals exhibiting fasting blood glucose levels 250 mgdL were selected and administered AETF orally at doses of 50 and 100 mgkg body weight per day for 28 consecutive days. Serum lipid parameters were quantified using enzymatic colourimetric assays. The STZ administration induced significant dyslipidaemia, characterised by elevated triglycerides, total cholesterol, LDL-C, and VLDL-C, along with reduced HDL-C, compared with normal controls (p