Phytochemical Composition, Antioxidant and Antibacterial Activities of <i>Calophyllum Canum</i> Hook. f. ex T. Anderson Extracts: Molecular Docking Insights
= 7.52 µg/mL), with a strong negative correlation (r = -0.968) between TPC and DPPH scavenging activity. Antibacterial testing against Acinetobacter baumannii revealed significant efficacy, with MIC values as low as 0.056 mg/mL. Molecular docking showed that gentisin had the highest binding energy against Penicillin-binding proteins (PBP). These findings emphasize the importance of solvent selection in bioactive compound extraction and highlight C. canum extracts as promising sources of natural antioxidants and antibacterial agents.
Authors
- Thiruventhan Karunakaran (ORCID: https://orcid.org/0000-0003-4470-2656)
- Kirnpal Kaur Banga Singh (ORCID: https://orcid.org/0000-0002-9958-5760)
- Mohamad Izwan Ismail (ORCID: https://orcid.org/0000-0002-2205-8372)
- Nor Hisam Zamakshshari (ORCID: https://orcid.org/0000-0003-1838-5116)
- Mas Atikah Lizazman (ORCID: https://orcid.org/0009-0002-9439-9384)
- Yiizamy Suffian
- Nik Zakuan Hakim Bin Nik Mohd Nazri
- Asla Marleena Nazeri
- Vivien Jong Yi Mian
Institutions
- Universiti Sains Malaysia (MY)
- Universiti Malaysia Sarawak (MY)
- Hospital Universiti Sains Malaysia (MY)
- Universiti Teknologi MARA (MY)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1002/cbdv.202500773
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00