PET imaging of polymyalgia rheumatica: update and future trends

F]FDG-PET/CT in both clinical and research settings relates directly to image acquisition and interpretation methods, as such consensus procedural guidelines have been developed to standardize imaging protocols. Recent advancements in PET technology, including long axial field-of-view (LAFOV) PET, dynamic and parametric imaging, radiomics and machine learning models may have potential applications in PMR. Furthermore, advances in the understanding of PMR immunopathology have highlighted potential roles for new imaging targets. Radiotracers targeting macrophages, T cells, fibroblasts, and angiogenesis-related pathways may improve disease characterization and offer insight into the molecular and cellular mechanisms involved in PMR pathogenesis. This review aims to summarize the current trends and future directions in image interpretation, PET technologies and potential targets for radiotracer development.