Senolytic Treatment Reduces Acute and Chronic Lung Inflammation in an Aged Mouse Model of Influenza
T cell responses, it did not affect influenza-specific antibody production nor pulmonary defense against reinfection. Notably, ABT-263 reduced long-term pulmonary sequelae including edema, type II hyperplasia, emphysema and epithelial damage. Overall, ABT-263 therapy partially mitigates influenza severity in aged mice, primarily through dampening acute and chronic inflammation. Most of these effects were age-dependent, suggesting a role for pre-existing senescent cells.
Authors
- Serge Adnot (ORCID: https://orcid.org/0000-0001-5666-3063)
- Séverine Heumel (ORCID: https://orcid.org/0000-0001-8649-5814)
- Clara Valentin
- Lou Delval (ORCID: https://orcid.org/0000-0002-3854-4439)
- Clément Bordas (ORCID: https://orcid.org/0000-0003-2325-5957)
- François Trottein (ORCID: https://orcid.org/0000-0003-3373-1814)
- Valentin Sencio (ORCID: https://orcid.org/0000-0002-6379-4317)
- Isabelle Wolowczuk (ORCID: https://orcid.org/0000-0001-6692-6904)
- Philippe Gosset (ORCID: https://orcid.org/0000-0002-4043-6429)
- David Claude Bernard
- Marybeth Creskey (ORCID: https://orcid.org/0000-0002-5884-1051)
- Lucie Deruyter
- Larissa Lipskaia (ORCID: https://orcid.org/0000-0002-7998-8378)
- Xu Zhang
- Stephano Raviola (ORCID: https://orcid.org/0000-0002-7626-2934)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Health Canada (CA)
- Centre National de la Recherche Scientifique (FR)
- University of Ottawa (CA)
- Inserm (FR)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Center for Infection and Immunity of Lille (FR)
- Centre Léon Bérard (FR)
- Centre de Recherche en Cancérologie de Lyon (FR)
- Institut Mondor de Recherche Biomédicale (FR)
Publication Details
- Journal
- Aging Cell
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1111/acel.70480
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Université de Lille
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Institute Pasteur De Lille