[ ⁸⁹ Zr]bevacizumab PET/CT imaging of vestibular schwannomas for the prediction of bevacizumab treatment effect in patients with symptomatic <i>NF2</i> -related schwannomatosis: a study protocol for a phase II single centre, prospective, f

INTRODUCTION: Treatment with bevacizumab achieves both tumour stabilisation or regression and preservation or improvement of hearing. However, the efficacy of bevacizumab varies between patients and within patients. Side effects due to bevacizumab treatment are also common. It would be of value to predict therapeutic response prior to initiating therapy to prevent unnecessary exposure in patients unlikely to benefit. METHODS AND ANALYSIS: Zr]bevacizumab uptake on PET/CT and changes in multiple hearing outcomes and radiological characteristics of the target tumour following treatment. Secondary outcome measures include vestibular functioning, patient reported outcome measures, cranial nerve functionality, peripheral neurology, non-target schwannoma response and renal function. Given the explorative nature of the study, associations between PET-derived metrics and clinical and radiological outcomes will be examined without formal hypothesis testing, using generalised estimating equations to account for within-patient correlation. Pairwise associations will be summarised in an association matrix with multiplicity addressed using an all-resolutions inference approach, and findings will be considered hypothesis generating. ETHICS AND DISSEMINATION: This study was submitted via the Clinical Trials Information System reviewed and approved by the Medical Research Ethics Committee Leiden-The Hague-Delft Delft. The study findings will be disseminated through publication in peer-reviewed scientific journals and by presentation at national and international conferences. TRIAL REGISTRATION NUMBER: The trial is registered at ClinicalTrials.gov Protocol Registration and Results System under the registration ID: NCT05685836.