First Study on Antimicrobial Susceptibility and Molecular Epidemiology of Neisseria gonorrhoeae Isolates from Infertile Women

Purpose: isolates obtained from infertile women in China. Methods: multiantigen sequence typing (NG-MAST). Results: Isolates were resistant to ciprofloxacin (100%), tetracycline (98.1%), penicillin (79.3%), and azithromycin (19.8%). In addition, 16.0% showed decreased susceptibility to ceftriaxone and 2.8% were resistant to ceftriaxone. Notably, 2.8% of the isolates displayed both azithromycin resistance and decreased susceptibility to ceftriaxone. NG-MAST identified 83 sequence types (STs), with ST5061 and ST4539 being the most common. Conclusion: Ceftriaxone monotherapy, rather than ceftriaxone-azithromycin dual therapy, may be an appropriate option for gonorrhea treatment in infertile women. Sustained surveillance of gonococcal antimicrobial resistance in infertile populations is warranted.